DECISÃO DE SAZONALIZAÇÃO DE CONTRATOS DE FORNECIMENTO DE ENERGIA ELÉTRICA NO BRASIL ATRAVÉS DA OTIMIZAÇÃO DA MEDIDA ÔMEGA (Ω)

Since the late 1990s, the Brazilian electric power industry has been undergoing significant structural changes, the main objective being to increase competition and resources allocation efficiency. Due to this increase in efficiency and because of seasonal electricity consumption, there is the inclusion of a contractual flexibility, named seazonalization. This flexibility in the contract allows the generation agent (hydropower plant) to choose the monthly electricity amount generated and supplied to the system, each year, within certain limits. In this article it is proposed a model for the analysis and decision of the best energy supply profile, for the twelve months of the contract time span, based on the optimization of the omega measurement (consider all moments), subjected to value at risk restrictions. In order for this omega measurement to be employed, the simulation of short term prices is used and the model then applied to a small hydroelectric generation facility. The results indicate that the seazonalization decision will change substantially when there are value at risk restrictions, forcing the optimal decision to be closer the flat allocation throughout the year.Desde o final dos anos 90, o setor elétrico brasileiro vem passando por grandes reformas, cujos principais objetivos são aumentar a competição e a eficiência na alocação de recursos. Exatamente em função deste aumento de eficiência na alocação de recursos e devido ao consumo sazonal de energia no Brasil, foi estabelecida uma flexibilidade para as hidrelétricas conhecida como sazonalização. A sazonalização permite que a cada ano o agente de geração declare para o próximo ano o quanto é a energia mensal respeitando-se certos limites. Neste artigo, propõe-se um modelo de análise de decisão da sazonalização a partir da otimização da medida ômega com restrições de valor em risco, a qual consegue incorporar todos os momentos de uma distribuição de probabilidade numa análise de decisão. Para o cálculo desta medida, utiliza-se simulação dos preços de curto prazo. Aplica-se este modelo ao caso de uma pequena central hidrelétrica. Os resultados indicam que a decisão de sazonalização muda substancialmente quando há restrição de valor em risco (Value at Risk - VaR), fazendo com que a decisão ótima fique mais próxima de uma alocação uniforme ao longo do ano. Quando não há restrição de VaR, a decisão ótima difere consideravelmente da alocação uniforme

Technology and motivation in the English teaching for young learners: What do teachers say?

Este trabalho tem como objetivo verificar a opinião de professoras sobre: a) a utilização de recursos tecnológicos no ensino de língua inglesa para crianças; e b) se esses recursos podem atuar como elemento motivacional nesse processo. A consecução do objetivo se deu através das análises, quantitativa e qualitativa, dos dados gerados por meio da aplicação de um questionário à seis professoras que atuam no ensino de inglês para crianças em um centro de aprendizagem de idiomas, localizado na cidade de Belém, estado do Pará. Assim, os resultados demonstram que grande parte das professoras utilizam algum tipo de recurso tecnológico durante suas aulas, e que todas acreditam que a utilização desses recursos motiva seus alunos durante o processo de ensino e aprendizagem de inglês.This work aims to verify the opinions of teachers about: a) the use of technological resources in teaching English to children; and b) if these resources can act as a motivating element in this process. These aims were achieved through quantitative and qualitative analysis of the data generated by a questionnaire that was answered by six teachers who work as English teachers for young learners at an  English school in Belém, located in the state of Pará. Thus, the results show that most teachers use some type of technological resource during their classes, and that all of them believe that the use of these resources motivates their students during the English teaching-learning process

IMPORTÂNCIA DOS EXAMES LABORATORIAIS NO DIAGNÓSTICO DA APENDICITE: UMA REVISÃO DA LITERATURA

A apendicite aguda é caracterizada como a doença inflamatória que afeta a espessura da parede do apêndice cecal, podendo apresentar-se em duas fases (inicial e tardia), as quais se correlacionam como o seu grau de evolução. O presente estudo de revisão objetivou descrever aspectos relacionados a fisiopatologia da apendicite aguda, relatando a importância dos exames laboratoriais para um diagnóstico eficaz, além de citar as contribuições de outras formas de diagnóstico e tratamento, úteis para um prognóstico favorável ao paciente. Trata-se de uma revisão da literatura com caráter descritivo e abordagem qualitativa, mediada a partir do uso das bases de dados Pubmed e Scielo, em um recorte temporal pré-estabelecido (2017 a 2022), onde, após aplicação dos descritores, foram encontrados 286 artigos, destes, após aplicação dos critérios de inclusão e exclusão, totalizaram 27artigos, os quais, configuram o presente estudo. Um dos principais exames laboratoriais que auxiliam no diagnóstico da apendicite é o hemograma, um exame simples e de fácil interpretação, que abriga importantes informações, úteis para um diagnóstico diferencial, principalmente quando associado aos dados obtidos na análise da Proteína C-reativa, exame de urina, exames de imagem e anamnese adequada do paciente

Recombination between heterologous human acrocentric chromosomes

The short arms of the human acrocentric chromosomes 13, 14, 15, 21 and 22 (SAACs) share large homologous regions, including ribosomal DNA repeats and extended segmental duplications1,2. Although the resolution of these regions in the first complete assembly of a human genome—the Telomere-to-Telomere Consortium’s CHM13 assembly (T2T-CHM13)—provided a model of their homology3, it remained unclear whether these patterns were ancestral or maintained by ongoing recombination exchange. Here we show that acrocentric chromosomes contain pseudo-homologous regions (PHRs) indicative of recombination between non-homologous sequences. Utilizing an all-to-all comparison of the human pangenome from the Human Pangenome Reference Consortium4 (HPRC), we find that contigs from all of the SAACs form a community. A variation graph5 constructed from centromere-spanning acrocentric contigs indicates the presence of regions in which most contigs appear nearly identical between heterologous acrocentric chromosomes in T2T-CHM13. Except on chromosome 15, we observe faster decay of linkage disequilibrium in the pseudo-homologous regions than in the corresponding short and long arms, indicating higher rates of recombination6,7. The pseudo-homologous regions include sequences that have previously been shown to lie at the breakpoint of Robertsonian translocations8, and their arrangement is compatible with crossover in inverted duplications on chromosomes 13, 14 and 21. The ubiquity of signals of recombination between heterologous acrocentric chromosomes seen in the HPRC draft pangenome suggests that these shared sequences form the basis for recurrent Robertsonian translocations, providing sequence and population-based confirmation of hypotheses first developed from cytogenetic studies 50 years ago9.Our work depends on the HPRC draft human pangenome resource established in the accompanying Article4, and we thank the production and assembly groups for their efforts in establishing this resource. This work used the computational resources of the UTHSC Octopus cluster and NIH HPC Biowulf cluster. We acknowledge support in maintaining these systems that was critical to our analyses. The authors thank M. Miller for the development of a graphical synopsis of our study (Fig. 5); and R. Williams and N. Soranzo for support and guidance in the design and discussion of our work. This work was supported, in part, by National Institutes of Health/NIDA U01DA047638 (E.G.), National Institutes of Health/NIGMS R01GM123489 (E.G.), NSF PPoSS Award no. 2118709 (E.G. and C.F.), the Tennessee Governor’s Chairs programme (C.F. and E.G.), National Institutes of Health/NCI R01CA266339 (T.P., L.G.d.L. and J.L.G.), and the Intramural Research Program of the National Human Genome Research Institute, National Institutes of Health (A.R., S.K. and A.M.P.). We acknowledge support from Human Technopole (A.G.), Consiglio Nazionale delle Ricerche, Italy (S.B. and V.C.), and Stowers Institute for Medical Research (T.P., L.G.d.L., B.R. and J.L.G.).Peer Reviewed"Article signat per 13 autors/es: Andrea Guarracino, Silvia Buonaiuto, Leonardo Gomes de Lima, Tamara Potapova, Arang Rhie, Sergey Koren, Boris Rubinstein, Christian Fischer, Human Pangenome Reference Consortium, Jennifer L. Gerton, Adam M. Phillippy, Vincenza Colonna & Erik Garrison " Human Pangenome Reference Consortium: "Haley J. Abel, Lucinda L. Antonacci-Fulton, Mobin Asri, Gunjan Baid, Carl A. Baker, Anastasiya Belyaeva, Konstantinos Billis, Guillaume Bourque, Silvia Buonaiuto, Andrew Carroll, Mark J. P. Chaisson, Pi-Chuan Chang, Xian H. Chang, Haoyu Cheng, Justin Chu, Sarah Cody, Vincenza Colonna, Daniel E. Cook, Robert M. Cook-Deegan, Omar E. Cornejo, Mark Diekhans, Daniel Doerr, Peter Ebert, Jana Ebler, Evan E. Eichler, Jordan M. Eizenga, Susan Fairley, Olivier Fedrigo, Adam L. Felsenfeld, Xiaowen Feng, Christian Fischer, Paul Flicek, Giulio Formenti, Adam Frankish, Robert S. Fulton, Yan Gao, Shilpa Garg, Erik Garrison, Nanibaa’ A. Garrison, Carlos Garcia Giron, Richard E. Green, Cristian Groza, Andrea Guarracino, Leanne Haggerty, Ira Hall, William T. Harvey, Marina Haukness, David Haussler, Simon Heumos, Glenn Hickey, Kendra Hoekzema, Thibaut Hourlier, Kerstin Howe, Miten Jain, Erich D. Jarvis, Hanlee P. Ji, Eimear E. Kenny, Barbara A. Koenig, Alexey Kolesnikov, Jan O. Korbel, Jennifer Kordosky, Sergey Koren, HoJoon Lee, Alexandra P. Lewis, Heng Li, Wen-Wei Liao, Shuangjia Lu, Tsung-Yu Lu, Julian K. Lucas, Hugo Magalhães, Santiago Marco-Sola, Pierre Marijon, Charles Markello, Tobias Marschall, Fergal J. Martin, Ann McCartney, Jennifer McDaniel, Karen H. Miga, Matthew W. Mitchell, Jean Monlong, Jacquelyn Mountcastle, Katherine M. Munson, Moses Njagi Mwaniki, Maria Nattestad, Adam M. Novak, Sergey Nurk, Hugh E. Olsen, Nathan D. Olson, Benedict Paten, Trevor Pesout, Adam M. Phillippy, Alice B. Popejoy, David Porubsky, Pjotr Prins, Daniela Puiu, Mikko Rautiainen, Allison A. Regier, Arang Rhie, Samuel Sacco, Ashley D. Sanders, Valerie A. Schneider, Baergen I. Schultz, Kishwar Shafin, Jonas A. Sibbesen, Jouni Sirén, Michael W. Smith, Heidi J. Sofia, Ahmad N. Abou Tayoun, Françoise Thibaud-Nissen, Chad Tomlinson, Francesca Floriana Tricomi, Flavia Villani, Mitchell R. Vollger, Justin Wagner, Brian Walenz, Ting Wang, Jonathan M. D. Wood, Aleksey V. Zimin & Justin M. Zook"Postprint (published version

Análise de Riscos pelo Uso de Métodos Ágeis na Gestão de Projetos de Desenvolvimento de Software

Agile Methodologies (AM) are offering improvements on several aspects of software development projects. However, its application involves risks, which are higher for some organizations and software projects. The objective of this work is to identify the main risks of applying AM in software development companies. The work involved an exploratory and qualitative research carried out by open and semi structured interviews with software project managers. Results show that many different risks can occur and with different impact on software projects. However, the main reasons behind all sort of risks are due to two aspects: (i) client involvement and (ii) experience and knowledge with agile practices.Métodos Ágeis (MA) têm promovido melhorias em diversos aspectos da gestão de projetos de desenvolvimento de software. No entanto, sua aplicação envolve riscos, que podem ser maiores em certas organizações ou contextos de projetos de software. O objetivo deste trabalho é analisar os principais riscos pela utilização de MA em empresas desenvolvedoras de software. O trabalho foi desenvolvido como pesquisa exploratória e qualitativa, com entrevistas abertas e semiestruturadas, com líderes de projetos de software. Resultados do trabalho mostram que diferentes tipos de riscos e impactos podem ocorrer em projetos ágeis. No entanto, as conclusões indicam que são apenas duas as principais causas de riscos: (i) engajamento de clientes e (ii) experiência e conhecimento com práticas ágeis

Can we use the questionnaire SNOT-22 as a predictor for the indication of surgical treatment in chronic rhinosinusitis?

Introduction: Chronic rhinosinusitis is a prevalent disease that has a negative impact on the lives of sufferers. SNOT-22 is considered the most appropriate questionnaire for assessing the quality of life of these patients and a very effective method of evaluating therapeutic interventionshowever it is not used as a tool for decision -making. Objective: To test the hypothesis that the SNOT-22 score can predict the outcome of surgical treatment. Methods: A retrospective, longitudinal and analytical study. We evaluated the medical records of patients with chronic rhinosinusitis that completed the SNOT-22 at the time of diagnosis. All the patients were consecutively receiving care at an otolaryngology service in Salvador, Bahia from August 2011 to June 2012. The outcomes of the surgical treatment of these patients were obtained from their medical records. The initial score was compared to a group of patients who were not referred for surgery. All the patients completed and signed a consent form. Results: Of the 88 patients with chronic rhinosinusitis, 26 had evolved to surgery over the last 3 years. The groups were homogeneous regarding gender and respiratory and medication allergies. The patients of the surgical group were 44.8 + 13.8 years old and the patients of the clinical group were 38.2 + 12.5 years old (p = 0.517). The average SNOT-22 score of the case group was 49 + 19 and the average score of the control group was 49 + 27 (p = 0.927). Conclusion: The SNOT-22 was unable to predict the outcome of surgical patients with chronic rhinosinusitis. (C) 2016 Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervico-Facial. Published by Elsevier Editora Ltda.Escola Bahiana Med & Saude Publ Bahiana, Programa Posgrad, Salvador, BA, BrazilUniv Fed Bahia UFBA, Salvador, BA, BrazilInst Otorrinolaringol Otorrinos Associados INOOA, Salvador, BA, BrazilSanta Casa Sao Paulo, Otorrinolaringol, Sao Paulo, SP, BrazilUniv Porto, Bioet, Oporto, PortugalUniv Fed Sao Paulo UNIFESP, Programa Posgrad Otorrinolaringol, Sao Paulo, SP, BrazilUniv Fed Sao Paulo UNIFESP, Programa Posgrad Otorrinolaringol, Sao Paulo, SP, BrazilWeb of Scienc

Efficacy and safety of very early mobilization after thrombolysis in acute ischemic stroke: a randomized clinical trial.

Stroke has a deleterious impact on human health due to its high incidence, degree of disabling sequelae and mortality, constituting one of the main causes of death and disability worldwide. This study aimed to assess the efficacy and safety of very early mobilization (VEMG) after thrombolysis in functional recovery in patients with acute ischemic stroke. The present study was an open, prospective, randomized study, with no blinded outcome, carried out in the stroke unit of a tertiary referral hospital located in Salvador-Bahia, Brazil. The primary outcome was the level of functional independence. Secondary outcomes were functional mobility, balance, complications within 7 days of hospitalization and 90 days after hospital discharge, and length of stay. A total of 104 patients with ischemic stroke who received thrombolytic treatment between August 2020 and July 2021 were prospectively recruited to the study. Of these, 51 patients received VEMG within 24 h of the ictus and another 53 patients receiving usual care (UCG) with mobilization 24 h after the ictus. When compared to the usual care, the VEMG group was not associated with a significant reduction in the risk of the primary outcome (relative risk [95% confidence intervals]: 0.74 [0.339-1.607]) or any of the secondary outcomes. In this study, the strategy of early mobilization after thrombolysis in ischemic stroke was safe, but without evidence of short-term benefit. Brazilian Registry of Clinical Trials under the registry (registry number: RBR-8bgcs3). [Abstract copyright: © 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.

Evidenciando o Consumo de Recursos Naturais pelas Companhias por meio de Indicadores de Eco-eficiência

This study aims to show, according to the accounting standards, what should or should not be recognized and/or disclosed as environmental liabilities. It also aims to verify through of a real case, the capacity of the Eco-efficiency Indicators of providing information that allow an evaluation of the companies’ consumption of natural resources in their activities. The company under study was the Companhia Siderúrgica de Tubarão (CST) within the period from 1999 to 2003. The findings show that the traditional accounting model contemplates the recognition and demonstration of the possible environmental liabilities when companies exceed the legal limits of pollution, and/or when they assume constructive environmental liabilities. We still conclude that the Eco-efficiency Indicators proposed by the ISAR/UNCTAD would meet satisfy, at least partially, society’s demands for information that allow an increased control over company’s actions regarding the consumption of natural resources within legal and constructive limits. Finally, we emphasize the results are valid only for the searched company, the specific case analyzed.Este estudo procura mostrar, de acordo com os padrões contábeis, o que deve ou não ser reconhecido e/ou evidenciado como passivos ambientais. Procura verificar ainda, por meio de um caso real, a capacidade dos eco-indicadores de eficiência ambiental de fornecer informações que permitam uma avaliação do consumo de recursos naturais pelas companhias em suas atividades. O estudo foi desenvolvido com dados reais da Companhia Siderúrgica de Tubarão (CST) no período de 1999-2003. Os resultados mostram que o modelo de contabilidade tradicional contempla o reconhecimento e demonstração dos possíveis passivos ambientais quando as empresas excedem os limites legais de poluição, e/ou quando assumem passivos ambientais construtivos. Conclui-se ainda que os indicadores de eficiência ambiental propostos pela ISAR/UNCTAD satisfazem, ao menos em parte, as demandas da sociedade por informações que permitam um controle maior das ações da companhia com relação ao consumo de recursos naturais dentro de limites legais e construtivos. Destaca-se que os resultados são válidos apenas para a empresa pesquisada, e para o caso específico analisado

Deficiência & os desafios para uma sociedade inclusiva

Divulgação dos SUMÁRIOS das obras recentemente incorporadas ao acervo da Biblioteca Ministro Oscar Saraiva do STJ. Em respeito à Lei de Direitos Autorais, não disponibilizamos a obra na íntegra.Localização na estante: 34-056.26 D313dOrganizado por: Igor Lima da Cruz Gomes, João Pedro Leite Barros e Leonardo Rocha de Almeida